ITN1383
ITN1383
ITN1383
from
$424.00
Price in reward points: 424
- Catalog: ITN1383
- Gene/Protein: SV2B KIAA0735
- Product Description: Immunotag™ SV2B Polyclonal Antibody
-
Description
-
Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein SV2B Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity SV2B Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name SV2B KIAA0735 Accession No. Q7L1I2 Q8BG39 Q63564 Description synaptic vesicle glycoprotein 2B(SV2B) Homo sapiens This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016], Cell Pathway/ Category ECM-receptor interaction, Protein Expression Brain,Testis, Subcellular Localization acrosomal vesicle,plasma membrane,synaptic vesicle,membrane,integral component of membrane,cell junction,synaptic vesicle membrane,neuron projection, Protein Function function:Probably plays a role in the control of regulated secretion in neural and endocrine cells.,PTM:N-glycosylated.,PTM:The N-terminal cytoplasmic domain is phosphorylated by CK1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids.,subunit:Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | SV2B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SV2B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SV2B KIAA0735 |
| Accession No. | Q7L1I2 Q8BG39 Q63564 |
| Description | synaptic vesicle glycoprotein 2B(SV2B) Homo sapiens This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016], |
| Cell Pathway/ Category | ECM-receptor interaction, |
| Protein Expression | Brain,Testis, |
| Subcellular Localization | acrosomal vesicle,plasma membrane,synaptic vesicle,membrane,integral component of membrane,cell junction,synaptic vesicle membrane,neuron projection, |
| Protein Function | function:Probably plays a role in the control of regulated secretion in neural and endocrine cells.,PTM:N-glycosylated.,PTM:The N-terminal cytoplasmic domain is phosphorylated by CK1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids.,subunit:Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |