ITN1413
ITN1413
- Catalog: ITN1413
- Gene/Protein: TM2D1 BBP
- Product Description: Immunotag™ TM2D1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TM2D1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TM2D1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TM2D1 BBP |
| Accession No. | Q9BX74 Q99MB3 |
| Description | TM2 domain containing 1(TM2D1) Homo sapiens The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016], |
| Protein Expression | Testis, |
| Subcellular Localization | nucleus,nucleoplasm,integral component of plasma membrane,integral component of membrane, |
| Protein Function | caution:Was initially thought (PubMed:11278849) to modulate beta-amyloid toxicity by coupling to G protein. However, PubMed:12836168 showed that this effect is not direct.,function:May participate to beta-amyloid-induced apoptosis via its interaction with beta-APP42.,PTM:N-glycosylated.,similarity:Belongs to the TM2 family.,subunit:Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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