ITN1506
ITN1506
- Catalog: ITN1506
- Gene/Protein: UTRN DMDL DRP1
- Product Description: Immunotag™ UTRO Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | UTRO |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p |
Recommended Dilution | IHC-p 1:50-300 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | UTRO Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | UTRN DMDL DRP1 |
Accession No. | P46939 |
Description | utrophin(UTRN) Homo sapiens This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008], |
Protein Expression | Epithelium,Muscle, |
Subcellular Localization | nucleoplasm,cytoplasm,cytoskeleton,plasma membrane,dystrophin-associated glycoprotein complex,membrane,cell junction,filopodium,growth cone,cortical actin cytoskeleton,filopodium membrane,neuromuscular junction,sarcolemma, |
Protein Function | function:May play a role in anchoring the cytoskeleton to the plasma membrane.,online information:Utrophin entry,similarity:Contains 1 WW domain.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 20 spectrin repeats.,subcellular location:Neuromuscular junction.,subunit:Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM.,tissue specificity:Muscle., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |