ITN1619
ITN1619
ITN1619
from
$424.00
Price in reward points: 424
- Catalog: ITN1619
- Gene/Protein: SIVA1 SIVA
- Product Description: Immunotag™ SIVA Polyclonal Antibody
-
Description
-
Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein SIVA Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity SIVA Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name SIVA1 SIVA Accession No. O15304 O54926 P59692 Description SIVA1 apoptosis inducing factor(SIVA1) Homo sapiens This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008], Protein Expression Cervix carcinoma,Monocytic leukemia,Ovary,Testis,Thymus, Subcellular Localization nucleoplasm,cytoplasm,mitochondrion, Protein Function cofactor:Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.,function:Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.,pharmaceutical:Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1.,PTM:Phosphorylated by ABL2/ARG in response to oxidative stress.,subcellular location:In the nucleus, accumulates in dot-like structures.,subunit:Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.,tissue specificity:Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | SIVA |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SIVA Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SIVA1 SIVA |
| Accession No. | O15304 O54926 P59692 |
| Description | SIVA1 apoptosis inducing factor(SIVA1) Homo sapiens This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008], |
| Protein Expression | Cervix carcinoma,Monocytic leukemia,Ovary,Testis,Thymus, |
| Subcellular Localization | nucleoplasm,cytoplasm,mitochondrion, |
| Protein Function | cofactor:Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.,function:Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.,pharmaceutical:Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1.,PTM:Phosphorylated by ABL2/ARG in response to oxidative stress.,subcellular location:In the nucleus, accumulates in dot-like structures.,subunit:Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.,tissue specificity:Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |