ITN1663
ITN1663
ITN1663
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- Catalog: ITN1663
- Gene/Protein: XRN1 SEP1
- Product Description: Immunotag™ XRN1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein XRN1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity XRN1 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name XRN1 SEP1 Accession No. Q8IZH2 P97789 Description 5'-3' exoribonuclease 1(XRN1) Homo sapiens This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013], Cell Pathway/ Category RNA degradation, Protein Expression Brain,Epithelium,Fetal kidney,Mesangial cell,Neuroblastoma,Small intestine,Testis, Subcellular Localization nucleus,cytoplasm,Golgi apparatus,cytosol,plasma membrane,membrane,intermediate filament cytoskeleton, Protein Function function:Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS).,induction:By GDNF.,miscellaneous:Down-regulated in OGS biopsy.,similarity:Belongs to the 5'-3' exonuclease family.,subcellular location:Discrete foci at the inner surface of the cell membrane.,subunit:Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1.,tissue specificity:Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | XRN1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | XRN1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | XRN1 SEP1 |
| Accession No. | Q8IZH2 P97789 |
| Description | 5'-3' exoribonuclease 1(XRN1) Homo sapiens This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013], |
| Cell Pathway/ Category | RNA degradation, |
| Protein Expression | Brain,Epithelium,Fetal kidney,Mesangial cell,Neuroblastoma,Small intestine,Testis, |
| Subcellular Localization | nucleus,cytoplasm,Golgi apparatus,cytosol,plasma membrane,membrane,intermediate filament cytoskeleton, |
| Protein Function | function:Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS).,induction:By GDNF.,miscellaneous:Down-regulated in OGS biopsy.,similarity:Belongs to the 5'-3' exonuclease family.,subcellular location:Discrete foci at the inner surface of the cell membrane.,subunit:Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1.,tissue specificity:Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |