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ITN1757

ITN1757
  • Gene/Protein: IL22RA2 UNQ5793/PRO19598/PRO19822
  • Product Description: Immunotag™ I22R2 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ I22R2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein I22R2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity I22R2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name IL22RA2 UNQ5793/PRO19598/PRO19822
Accession No. Q969J5 Q80XF5 Q7TNI4
Description interleukin 22 receptor subunit alpha 2(IL22RA2) Homo sapiens This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013],
Cell Pathway/ Category Cytokine-cytokine receptor interaction,Jak_STAT,
Protein Expression Mammary gland,Placenta,
Subcellular Localization extracellular region,extracellular space,cytosol,plasma membrane,integral component of membrane,
Protein Function function:Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 3 fibronectin type-III domains.,tissue specificity:Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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