ITN1788
ITN1788
ITN1788
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Price in reward points: 424
- Catalog: ITN1788
- Gene/Protein: PLCB4
- Product Description: Immunotag™ PLCB4 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PLCB4 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species H,Rat Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity PLCB4 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name PLCB4 Accession No. Q15147 Q9QW07 Description phospholipase C beta 4(PLCB4) Homo sapiens The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010], Cell Pathway/ Category Inositol phosphate metabolism,Calcium,Chemokine,Phosphatidylinositol signaling system,Vascular smooth muscle contraction,WNT,WNT-T CELLGap junction,Long-term potentiation,Long-term depression,GnRH,Melanogenesis,Alzheimer's disease,Huntington's disease, Protein Expression Brain,Epithelium,Ovarian carcinoma,Retina, Subcellular Localization intracellular,nucleus,smooth endoplasmic reticulum,cytosol,postsynaptic density,dendrite, Protein Function Additional isoforms seem to exist,catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,tissue specificity:Preferentially expressed in the retina., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PLCB4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | H,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PLCB4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PLCB4 |
| Accession No. | Q15147 Q9QW07 |
| Description | phospholipase C beta 4(PLCB4) Homo sapiens The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010], |
| Cell Pathway/ Category | Inositol phosphate metabolism,Calcium,Chemokine,Phosphatidylinositol signaling system,Vascular smooth muscle contraction,WNT,WNT-T CELLGap junction,Long-term potentiation,Long-term depression,GnRH,Melanogenesis,Alzheimer's disease,Huntington's disease, |
| Protein Expression | Brain,Epithelium,Ovarian carcinoma,Retina, |
| Subcellular Localization | intracellular,nucleus,smooth endoplasmic reticulum,cytosol,postsynaptic density,dendrite, |
| Protein Function | Additional isoforms seem to exist,catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,tissue specificity:Preferentially expressed in the retina., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |