ITN1841
ITN1841
- Catalog: ITN1841
- Gene/Protein: PIK3CB PIK3C1
- Product Description: Immunotag™ PK3CB Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PK3CB |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PK3CB Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PIK3CB PIK3C1 |
| Accession No. | P42338 Q8BTI9 Q9Z1L0 |
| Description | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta(PIK3CB) Homo sapiens This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011], |
| Cell Pathway/ Category | Inositol phosphate metabolism,ErbB_HER,Chemokine,Phosphatidylinositol signaling system,mTOR,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,VEGF,Focal adhesion,Toll_Like,Jak_STAT,Natural killer cell mediated cytotoxicity,T_Cell_Receptor,B_Cell_Antigen,Fc epsilon RI,Fc gamma R-mediated phagocytosis,Leukocyte transendothelial migration,Neurotrophin,Regulates Actin and Cytoskeleton,Insulin_Receptor,Progesterone-mediated oocyte maturation,Type II diabetes mellitus,Aldosterone-regulated sodium reabsorption,Pathways in cancer,Colorectal cancer,Renal cell carcinoma,Pancreatic cancer,Endometrial cancer,Glioma,Prostate cancer,Melanoma,Chronic myeloid leukemia,Acute myeloid leukemia,Small cell lung cancer,Non-small cell lung cancer, |
| Protein Expression | Liver,Placenta,Skeletal muscle, |
| Subcellular Localization | intracellular,nucleus,nucleolus,cytosol,plasma membrane,phosphatidylinositol 3-kinase complex,intercellular bridge, |
| Protein Function | catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,function:Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.,tissue specificity:Expressed ubiquitously., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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