Datasheet |
|
Target Protein |
KCC2B |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
WB,ELISA |
Recommended Dilution |
WB 1:500-2000 ELISA 1:5000-20000 |
Concentration |
1 mg/ml |
Reactive Species |
Human |
Host Species |
Rabbit |
Immunogen |
Synthesized peptide derived from part region of human protein |
Specificity |
KCC2B Polyclonal Antibody detects endogenous levels of protein. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name |
CAMK2B CAM2 CAMK2 CAMKB |
Accession No. |
Q13554 P28652 P08413 |
Description |
calcium/calmodulin dependent protein kinase II beta(CAMK2B) Homo sapiens The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], |
Cell Pathway/ Category |
ErbB_HER,Calcium,Oocyte meiosis,WNT,WNT-T CELLLong-term potentiation,Neurotrophin,Olfactory transduction,GnRH,Melanogenesis,Glioma, |
Protein Expression |
Brain,Insulinoma,Lung,Skeletal muscle, |
Subcellular Localization |
nucleoplasm,microtubule organizing center,cytosol,plasma membrane,endocytic vesicle membrane,sarcoplasmic reticulum membrane, |
Protein Function |
The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |