ITN1870
ITN1870
- Catalog: ITN1870
- Gene/Protein: NEK2 NEK2A NLK1
- Product Description: Immunotag™ NEK2 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | NEK2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | NEK2 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | NEK2 NEK2A NLK1 |
Accession No. | P51955 O35942 |
Description | NIMA related kinase 2(NEK2) Homo sapiens This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011], |
Protein Expression | Mammary gland,Nasopharynx,Placenta,Platelet,Skin,T-cell,Testis,Uterus, |
Subcellular Localization | kinetochore,condensed chromosome kinetochore,condensed nuclear chromosome,spindle pole,nucleus,nucleolus,cytoplasm,centrosome,cytosol,microtubule,midbody,protein complex, |
Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,developmental stage:Accumulates throughout S phase and shows maximal levels in late G2. This expression pattern is highly reminiscent of that of A and B cyclins. Expression of both isoform 1 and isoform 2 is low in the G1 phase and increases in the S/G2 phases. Isoform 1 is absent from cells arrested in the G2/M prometaphase, whereas isoform 2 remains present.,function:Protein kinase that is involved in mitotic regulation. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.,PTM:It is unsure whether Thr-170 or Ser-171 is phosphorylated.,similarity:Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end.,subcellular location:Predominantly cytoplasmic.,subunit:Interacts with TERF1. Isoform 1 and isoform 2 form homo-and heterodimers.,tissue specificity:Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |