ITN2064
ITN2064
- Catalog: ITN2064
- Gene/Protein: FKBP1B FKBP12.6 FKBP1L FKBP9 OTK4
- Product Description: Immunotag™ FKB1B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FKB1B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | FKB1B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | FKBP1B FKBP12.6 FKBP1L FKBP9 OTK4 |
| Accession No. | P68106 Q9Z2I2 P97534 |
| Description | FK506 binding protein 1B(FKBP1B) Homo sapiens The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Fetal brain,Heart muscle, |
| Subcellular Localization | cytoplasm,cytosol,membrane,Z disc,sarcoplasmic reticulum membrane,calcium channel complex, |
| Protein Function | catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by both FK506 and rapamycin.,function:Associates with the ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the FKBP-type PPIase family. FKBP1 subfamily.,similarity:Contains 1 PPIase FKBP-type domain.,tissue specificity:Ubiquitous for both isoforms with highest levels in brain and thymus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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