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ITN2202

  • Gene/Protein: GPNMB HGFIN NMB UNQ1725/PRO9925
  • Product Description: Immunotag™ GPNMB Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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ITN2202

Immunotag™ GPNMB Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein GPNMB
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity GPNMB Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name GPNMB HGFIN NMB UNQ1725/PRO9925
Accession No. Q14956 Q99P91 Q6P7C7
Description glycoprotein nmb(GPNMB) Homo sapiens The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Protein Expression Brain,Liver,Melanoma,Peripheral blood,Skin,
Subcellular Localization plasma membrane,integral component of plasma membrane,integral component of membrane,melanosome,
Protein Function developmental stage:Expression in poorly metastatic melanoma cell lines; no expression in highly metastatic melanoma cell lines.,function:Could be a melanogenic enzyme.,similarity:Belongs to the Pmel-17/NMB family.,similarity:Contains 1 PKD domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Not restricted to the melanocytic lineage.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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