ITN2418
ITN2418
ITN2418
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- Catalog: ITN2418
- Gene/Protein: LECT1 CHMI
- Product Description: Immunotag™ LECT1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein LECT1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein, at AA range: 150-230 Specificity LECT1 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name LECT1 CHMI Accession No. O75829 Q9Z1F6 O70367 Description leukocyte cell derived chemotaxin 1(LECT1) Homo sapiens This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularizat Protein Expression Chondrosarcoma, Subcellular Localization proteinaceous extracellular matrix,endomembrane system,integral component of membrane, Protein Function developmental stage:Expressed at 9 weeks in developing cartilagenous bone rudiments.,function:Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.,PTM:After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.,similarity:Belongs to the chondromodulin-1 family.,similarity:Contains 1 BRICHOS domain.,subcellular location:Accumulated in the inter-territorial matrix of cartilage.,tissue specificity:Cartilage specific. Weakly expressed in chondrosarcoma., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | LECT1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 150-230 |
| Specificity | LECT1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | LECT1 CHMI |
| Accession No. | O75829 Q9Z1F6 O70367 |
| Description | leukocyte cell derived chemotaxin 1(LECT1) Homo sapiens This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularizat |
| Protein Expression | Chondrosarcoma, |
| Subcellular Localization | proteinaceous extracellular matrix,endomembrane system,integral component of membrane, |
| Protein Function | developmental stage:Expressed at 9 weeks in developing cartilagenous bone rudiments.,function:Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.,PTM:After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.,similarity:Belongs to the chondromodulin-1 family.,similarity:Contains 1 BRICHOS domain.,subcellular location:Accumulated in the inter-territorial matrix of cartilage.,tissue specificity:Cartilage specific. Weakly expressed in chondrosarcoma., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |