ITN2431
ITN2431
ITN2431
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- Catalog: ITN2431
- Gene/Protein: RHCE RHC RHE
- Product Description: Immunotag™ RHCE Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein RHCE Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 161-210 Specificity RHCE Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name RHCE RHC RHE Accession No. P18577 Description Rh blood group CcEe antigens(RHCE) Homo sapiens The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016], Protein Expression Blood,Bone marrow,Brain,Colon,Peripheral blood,Peripheral whole blood, Subcellular Localization integral component of plasma membrane,membrane,integral component of membrane, Protein Function function:May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.,online information:Blood group antigen gene mutation database,polymorphism:RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.,similarity:Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.,tissue specificity:Restricted to tissues or cell lines expressing erythroid characters., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | RHCE |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 161-210 |
| Specificity | RHCE Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | RHCE RHC RHE |
| Accession No. | P18577 |
| Description | Rh blood group CcEe antigens(RHCE) Homo sapiens The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016], |
| Protein Expression | Blood,Bone marrow,Brain,Colon,Peripheral blood,Peripheral whole blood, |
| Subcellular Localization | integral component of plasma membrane,membrane,integral component of membrane, |
| Protein Function | function:May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.,online information:Blood group antigen gene mutation database,polymorphism:RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.,similarity:Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.,tissue specificity:Restricted to tissues or cell lines expressing erythroid characters., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |