ITN2869
ITN2869
ITN2869
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- Catalog: ITN2869
- Gene/Protein: PMVK PMKI
- Product Description: Immunotag™ PMVK Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PMVK Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity PMVK Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name PMVK PMKI Accession No. Q15126 Q9D1G2 Description phosphomevalonate kinase(PMVK) Homo sapiens This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011], Cell Pathway/ Category Terpenoid backbone biosynthesis, Protein Expression Liver,Skin,Testis,Uterus, Subcellular Localization cytoplasm,peroxisome,cytosol,membrane,extracellular exosome, Protein Function catalytic activity:ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.,induction:By sterol.,pathway:Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonic acid pathway; isopentenyl-PP from (R)-mevalonic acid: step 2/3.,subunit:Monomer.,tissue specificity:Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta, and lung., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PMVK |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PMVK Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PMVK PMKI |
| Accession No. | Q15126 Q9D1G2 |
| Description | phosphomevalonate kinase(PMVK) Homo sapiens This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011], |
| Cell Pathway/ Category | Terpenoid backbone biosynthesis, |
| Protein Expression | Liver,Skin,Testis,Uterus, |
| Subcellular Localization | cytoplasm,peroxisome,cytosol,membrane,extracellular exosome, |
| Protein Function | catalytic activity:ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.,induction:By sterol.,pathway:Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonic acid pathway; isopentenyl-PP from (R)-mevalonic acid: step 2/3.,subunit:Monomer.,tissue specificity:Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta, and lung., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |