ITN2896
ITN2896
ITN2896
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$424.00
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- Catalog: ITN2896
- Gene/Protein: HLA-G HLA-6.0 HLAG
- Product Description: Immunotag™ HLAG Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein HLAG Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity HLAG Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name HLA-G HLA-6.0 HLAG Accession No. P17693 Description major histocompatibility complex, class I, G(HLA-G) Homo sapiens HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Endocytosis,Cell adhesion molecules (CAMs),Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Type I diabetes mellitus,Autoimmune thyroid disease,Allograft rejection,Graft-versus-host disease,Viral myocarditis, Protein Expression Blood,Fetal eye,Peripheral blood,Peripheral blood leukocyte Subcellular Localization Golgi membrane,plasma membrane,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,phagocytic vesicle membrane,early endosome membrane,MHC class I protein complex,integral component of lumenal side of endoplasm Protein Function function:Involved in the presentation of foreign antigens to the immune system.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).,tissue specificity:Expression of HLAG seems to be restricted to eye cells and tissue., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | HLAG |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | HLAG Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | HLA-G HLA-6.0 HLAG |
| Accession No. | P17693 |
| Description | major histocompatibility complex, class I, G(HLA-G) Homo sapiens HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Endocytosis,Cell adhesion molecules (CAMs),Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Type I diabetes mellitus,Autoimmune thyroid disease,Allograft rejection,Graft-versus-host disease,Viral myocarditis, |
| Protein Expression | Blood,Fetal eye,Peripheral blood,Peripheral blood leukocyte |
| Subcellular Localization | Golgi membrane,plasma membrane,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,phagocytic vesicle membrane,early endosome membrane,MHC class I protein complex,integral component of lumenal side of endoplasm |
| Protein Function | function:Involved in the presentation of foreign antigens to the immune system.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).,tissue specificity:Expression of HLAG seems to be restricted to eye cells and tissue., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |