ITN2909
ITN2909
ITN2909
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$424.00
Price in reward points: 424
- Catalog: ITN2909
- Gene/Protein: NPHS2
- Product Description: Immunotag™ PODO Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PODO Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity PODO Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name NPHS2 Accession No. Q9NP85 Q91X05 Q8K4G9 Description NPHS2, podocin(NPHS2) Homo sapiens This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], Protein Expression Colon,Kidney, Subcellular Localization endoplasmic reticulum,plasma membrane,integral component of plasma membrane,cell-cell junction,intrinsic component of the cytoplasmic side of the plasma membrane,slit diaphragm,protein complex,membrane raft,extracellular exosome, Protein Function disease:Defects in NPHS2 are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN) [MIM:600995]. SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. Focal segmental glomerulosclerosis is present at later stages.,function:Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.,similarity:Belongs to the band 7/mec-2 family.,subunit:Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN.,tissue specificity:Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PODO |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PODO Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NPHS2 |
| Accession No. | Q9NP85 Q91X05 Q8K4G9 |
| Description | NPHS2, podocin(NPHS2) Homo sapiens This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], |
| Protein Expression | Colon,Kidney, |
| Subcellular Localization | endoplasmic reticulum,plasma membrane,integral component of plasma membrane,cell-cell junction,intrinsic component of the cytoplasmic side of the plasma membrane,slit diaphragm,protein complex,membrane raft,extracellular exosome, |
| Protein Function | disease:Defects in NPHS2 are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN) [MIM:600995]. SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. Focal segmental glomerulosclerosis is present at later stages.,function:Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.,similarity:Belongs to the band 7/mec-2 family.,subunit:Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN.,tissue specificity:Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |