ITN2921
ITN2921
- Catalog: ITN2921
- Gene/Protein: TBX21 TBET TBLYM
- Product Description: Immunotag™ TBX21 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TBX21 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TBX21 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TBX21 TBET TBLYM |
| Accession No. | Q9UL17 Q9JKD8 |
| Description | T-box 21(TBX21) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008], |
| Protein Expression | Spleen,Testis, |
| Subcellular Localization | nucleus,neuronal cell body, |
| Protein Function | disease:Genetic variations in TBX21 are associated with susceptibility to aspirin-induced asthma [MIM:208550]. Asthma is defined as a chronic inflammatory lung disease that is characterized by airway hyperreactivity, eosinophil inflammation, and mucus hypersecretion resulting in intermittent airway obstruction.,disease:Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps [MIM:208550]. Nasal polyps is a chronic inflammatory disease of the paranasal sinus mucosa, leading to the protrusion of edematous polyps into the nasal cavities.,function:Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:T-cell specific., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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