ITN2968
ITN2968
- Catalog: ITN2968
- Gene/Protein: IDH3G
- Product Description: Immunotag™ IDH3G Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | IDH3G |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | IDH3G Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | IDH3G |
Accession No. | P51553 |
Description | isocitrate dehydrogenase 3 (NAD(+)) gamma(IDH3G) Homo sapiens Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for p |
Cell Pathway/ Category | Citrate cycle (TCA cycle), |
Protein Expression | Brain,Heart,Placenta,Skin,Soares liver spleen 1NFLS, |
Subcellular Localization | nucleoplasm,nucleolus,mitochondrion,mitochondrial matrix, |
Protein Function | catalytic activity:Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.,cofactor:Binds 1 magnesium or manganese ion per subunit.,enzyme regulation:Activated by increasing ADP/ATP ratios and by Ca(2+).,similarity:Belongs to the isocitrate and isopropylmalate dehydrogenases family.,subunit:Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |