ITP0336
ITP0336
ITP0336
from
$541.00
Price in reward points: 541
- Catalog: ITP0336
- Gene/Protein: ATRIP
- Product Description: Immunotag™ ATRIP (phospho Ser68) Polyclonal Antibody
-
Description
-
Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein ATRIP (Ser68) Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human ATRIP around the phosphorylation site of Ser68. AA range:34-83 Specificity Phospho-ATRIP (S68) Polyclonal Antibody detects endogenous levels of ATRIP protein only when phosphorylated at S68. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name ATRIP Accession No. Q8WXE1 Q8BMG1 Alternate Names ATRIP; AGS1; ATR-interacting protein; ATM and Rad3-related-interacting protein Description ATR interacting protein(ATRIP) Homo sapiens This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012], Protein Expression Colon,Endothelial cell,Epithelium,Fetal brain,Lung adenocarcinoma,Lymph,Melanoma,Pl Subcellular Localization nucleoplasm, Protein Function caution:The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,function:Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.,PTM:Phosphorylated by ATR.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the ATRIP family.,subcellular location:Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus).,tissue specificity:Ubiquitous., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | ATRIP (Ser68) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATRIP around the phosphorylation site of Ser68. AA range:34-83 |
| Specificity | Phospho-ATRIP (S68) Polyclonal Antibody detects endogenous levels of ATRIP protein only when phosphorylated at S68. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ATRIP |
| Accession No. | Q8WXE1 Q8BMG1 |
| Alternate Names | ATRIP; AGS1; ATR-interacting protein; ATM and Rad3-related-interacting protein |
| Description | ATR interacting protein(ATRIP) Homo sapiens This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012], |
| Protein Expression | Colon,Endothelial cell,Epithelium,Fetal brain,Lung adenocarcinoma,Lymph,Melanoma,Pl |
| Subcellular Localization | nucleoplasm, |
| Protein Function | caution:The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,function:Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.,PTM:Phosphorylated by ATR.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the ATRIP family.,subcellular location:Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus).,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |