ITP0828
ITP0828
ITP0828
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- Catalog: ITP0828
- Gene/Protein: NCF1
- Product Description: Immunotag™ p47-phox (phospho Ser345) Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein p47-pHOX (Ser345) Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC-p,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser345. AA range:311-360 Specificity Phospho-p47-phox (S345) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S345. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name NCF1 Accession No. P14598 Q09014 Alternate Names NCF1; NOXO2; SH3PXD1A; Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 Description neutrophil cytosolic factor 1(NCF1) Homo sapiens The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Chemokine,Fc gamma R-mediated phagocytosis,Leukocyte transendothelial migration, Protein Expression Lymph,Ovary,Spleen,Synovium,Umbilical vein, Subcellular Localization cytoplasm,rough endoplasmic reticulum,Golgi apparatus,cytosol,extrinsic component of membrane,dendrite,phagolysosome,NADPH oxidase complex,neuronal cell body, Protein Function disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | p47-pHOX (Ser345) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser345. AA range:311-360 |
| Specificity | Phospho-p47-phox (S345) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S345. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NCF1 |
| Accession No. | P14598 Q09014 |
| Alternate Names | NCF1; NOXO2; SH3PXD1A; Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 |
| Description | neutrophil cytosolic factor 1(NCF1) Homo sapiens The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Chemokine,Fc gamma R-mediated phagocytosis,Leukocyte transendothelial migration, |
| Protein Expression | Lymph,Ovary,Spleen,Synovium,Umbilical vein, |
| Subcellular Localization | cytoplasm,rough endoplasmic reticulum,Golgi apparatus,cytosol,extrinsic component of membrane,dendrite,phagolysosome,NADPH oxidase complex,neuronal cell body, |
| Protein Function | disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |