ITP0878
ITP0878
- Catalog: ITP0878
- Gene/Protein: ETS1
- Product Description: Immunotag™ Ets-1 (phospho Thr38) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ETS1 (Thr38) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Ets-1 (phospho Thr38) |
| Specificity | Phospho-Ets-1 (T38) Polyclonal Antibody detects endogenous levels of Ets-1 protein only when phosphorylated at T38. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ETS1 |
| Accession No. | P14921 P27577 P41156 |
| Alternate Names | ETS1; EWSR2; Protein C-ets-1; p54 |
| Description | ETS proto-oncogene 1, transcription factor(ETS1) Homo sapiens This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011], |
| Cell Pathway/ Category | Dorso-ventral axis formation,Pathways in cancer,Renal cell carcinoma, |
| Protein Expression | Human endometrium,Lung,Synovial membrane tissue, |
| Subcellular Localization | nucleus,nucleoplasm,transcription factor complex,cytoplasm, |
| Protein Function | disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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