ITP1136
ITP1136
ITP1136
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$541.00
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- Catalog: ITP1136
- Gene/Protein: PLD1
- Product Description: Immunotag™ PC-PLD1 (phospho Ser561) Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PC-PLD1 (Ser561) Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,IF,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized phospho-peptide around the phosphorylation site of human PC-PLD1 (phospho Ser561) Specificity Phospho-PC-PLD1 (S561) Polyclonal Antibody detects endogenous levels of PC-PLD1 protein only when phosphorylated at S561. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name PLD1 Accession No. Q13393 Q9Z280 P70496 Alternate Names PLD1; Phospholipase D1; PLD 1; hPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1 Description phospholipase D1(PLD1) Homo sapiens This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011], Cell Pathway/ Category Glycerophospholipid metabolism,Ether lipid metabolism,Endocytosis,Fc gamma R-mediated phagocytosis,GnRH,Pathways in cancer,Pancreatic cancer, Protein Expression Aorta endothelial cell,Brain,Cervix carcinoma,Chondrocyte,Epithelium,Skeletal muscle,Testis Subcellular Localization Golgi membrane,lysosomal membrane,endosome,endoplasmic reticulum membrane,Golgi apparatus,membrane,apical plasma membrane,endocytic vesicle,late endosome membrane,perinuclear region of cytoplasm, Protein Function catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.,function:Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with PIP5K1A.,tissue specificity:Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PC-PLD1 (Ser561) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human PC-PLD1 (phospho Ser561) |
| Specificity | Phospho-PC-PLD1 (S561) Polyclonal Antibody detects endogenous levels of PC-PLD1 protein only when phosphorylated at S561. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PLD1 |
| Accession No. | Q13393 Q9Z280 P70496 |
| Alternate Names | PLD1; Phospholipase D1; PLD 1; hPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1 |
| Description | phospholipase D1(PLD1) Homo sapiens This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011], |
| Cell Pathway/ Category | Glycerophospholipid metabolism,Ether lipid metabolism,Endocytosis,Fc gamma R-mediated phagocytosis,GnRH,Pathways in cancer,Pancreatic cancer, |
| Protein Expression | Aorta endothelial cell,Brain,Cervix carcinoma,Chondrocyte,Epithelium,Skeletal muscle,Testis |
| Subcellular Localization | Golgi membrane,lysosomal membrane,endosome,endoplasmic reticulum membrane,Golgi apparatus,membrane,apical plasma membrane,endocytic vesicle,late endosome membrane,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.,function:Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with PIP5K1A.,tissue specificity:Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |