ITT0030
ITT0030
ITT0030
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$424.00
Price in reward points: 424
- Catalog: ITT0030
- Gene/Protein: ADCY4
- Product Description: Immunotag™ A Cyclase IV Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein A Cyclase IV Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from A Cyclase IV, at AA range: 170-250 Specificity A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name ADCY4 Accession No. Q8NFM4 Q91WF3 P26770 Alternate Names ADCY4; Adenylate cyclase type 4; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4 Description adenylate cyclase 4(ADCY4) Homo sapiens This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010], Cell Pathway/ Category Purine metabolism,Calcium,Chemokine,Oocyte meiosis,Vascular smooth muscle contraction,Gap junction,Taste transduction,GnRH,Progesterone-mediated oocyte maturation,Melanogenesis,Dilated cardiomyopathy, Protein Expression Lung,Placenta,Spleen,Testis,Uterus, Subcellular Localization intracellular,cytoplasm,plasma membrane,membrane,integral component of membrane,dendrite, Protein Function catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | A Cyclase IV |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from A Cyclase IV, at AA range: 170-250 |
| Specificity | A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ADCY4 |
| Accession No. | Q8NFM4 Q91WF3 P26770 |
| Alternate Names | ADCY4; Adenylate cyclase type 4; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4 |
| Description | adenylate cyclase 4(ADCY4) Homo sapiens This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010], |
| Cell Pathway/ Category | Purine metabolism,Calcium,Chemokine,Oocyte meiosis,Vascular smooth muscle contraction,Gap junction,Taste transduction,GnRH,Progesterone-mediated oocyte maturation,Melanogenesis,Dilated cardiomyopathy, |
| Protein Expression | Lung,Placenta,Spleen,Testis,Uterus, |
| Subcellular Localization | intracellular,cytoplasm,plasma membrane,membrane,integral component of membrane,dendrite, |
| Protein Function | catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |