ITT0030
ITT0030
- Catalog: ITT0030
- Gene/Protein: ADCY4
- Product Description: Immunotag™ A Cyclase IV Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | A Cyclase IV |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from A Cyclase IV, at AA range: 170-250 |
Specificity | A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | ADCY4 |
Accession No. | Q8NFM4 Q91WF3 P26770 |
Alternate Names | ADCY4; Adenylate cyclase type 4; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4 |
Description | adenylate cyclase 4(ADCY4) Homo sapiens This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010], |
Cell Pathway/ Category | Purine metabolism,Calcium,Chemokine,Oocyte meiosis,Vascular smooth muscle contraction,Gap junction,Taste transduction,GnRH,Progesterone-mediated oocyte maturation,Melanogenesis,Dilated cardiomyopathy, |
Protein Expression | Lung,Placenta,Spleen,Testis,Uterus, |
Subcellular Localization | intracellular,cytoplasm,plasma membrane,membrane,integral component of membrane,dendrite, |
Protein Function | catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |