ITT1278
ITT1278
ITT1278
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Price in reward points: 424
- Catalog: ITT1278
- Gene/Protein: DRD4
- Product Description: Immunotag™ D4DR Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein D4DR Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IF,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from D4DR, at AA range: 330-410 Specificity D4DR Polyclonal Antibody detects endogenous levels of D4DR protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name DRD4 Accession No. P21917 P51436 P30729 Alternate Names DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor Description dopamine receptor D4(DRD4) Homo sapiens This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Neuroactive ligand-receptor interaction, Protein Expression Brain, Subcellular Localization plasma membrane,integral component of plasma membrane,membrane,postsynapse, Protein Function function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6 (By similarity) and GPRASP1., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | D4DR |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from D4DR, at AA range: 330-410 |
| Specificity | D4DR Polyclonal Antibody detects endogenous levels of D4DR protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | DRD4 |
| Accession No. | P21917 P51436 P30729 |
| Alternate Names | DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor |
| Description | dopamine receptor D4(DRD4) Homo sapiens This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,membrane,postsynapse, |
| Protein Function | function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6 (By similarity) and GPRASP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |