ITT1296
ITT1296
ITT1296
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- Catalog: ITT1296
- Gene/Protein: DBH
- Product Description: Immunotag™ DBH Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein DBH Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human DBH. AA range:401-450 Specificity DBH Polyclonal Antibody detects endogenous levels of DBH protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name DBH Accession No. P09172 Q64237 Alternate Names DBH; Dopamine beta-hydroxylase; Dopamine beta-monooxygenase Description dopamine beta-hydroxylase(DBH) Homo sapiens The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Tyrosine metabolism, Protein Expression Brain,Plasma, Subcellular Localization extracellular region,extracellular space,cytoplasm,membrane,integral component of membrane,transport vesicle membrane,secretory granule membrane,chromaffin granule lumen,secretory granule lumen,chromaffin granule membrane, Protein Function catalytic activity:3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)O.,cofactor:Binds 1 PQQ per subunit.,cofactor:Binds 2 copper ions per subunit.,disease:Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.,function:Conversion of dopamine to noradrenaline.,induction:Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.,online information:Dopamine beta hydroxylase entry,pathway:Catecholamine biosynthesis; norepinephrine biosynthesis; norepinephrine from dopamine: step 1/1.,polymorphism:There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318.,similarity:Belongs to the copper type II ascorbate-dependent monooxygenase family.,similarity:Contains 1 DOMON domain.,subunit:Homotetramer composed of two non-covalently bound disulfide-linked dimers., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | DBH |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DBH. AA range:401-450 |
| Specificity | DBH Polyclonal Antibody detects endogenous levels of DBH protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | DBH |
| Accession No. | P09172 Q64237 |
| Alternate Names | DBH; Dopamine beta-hydroxylase; Dopamine beta-monooxygenase |
| Description | dopamine beta-hydroxylase(DBH) Homo sapiens The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Tyrosine metabolism, |
| Protein Expression | Brain,Plasma, |
| Subcellular Localization | extracellular region,extracellular space,cytoplasm,membrane,integral component of membrane,transport vesicle membrane,secretory granule membrane,chromaffin granule lumen,secretory granule lumen,chromaffin granule membrane, |
| Protein Function | catalytic activity:3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)O.,cofactor:Binds 1 PQQ per subunit.,cofactor:Binds 2 copper ions per subunit.,disease:Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.,function:Conversion of dopamine to noradrenaline.,induction:Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.,online information:Dopamine beta hydroxylase entry,pathway:Catecholamine biosynthesis; norepinephrine biosynthesis; norepinephrine from dopamine: step 1/1.,polymorphism:There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318.,similarity:Belongs to the copper type II ascorbate-dependent monooxygenase family.,similarity:Contains 1 DOMON domain.,subunit:Homotetramer composed of two non-covalently bound disulfide-linked dimers., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |