ITT1416
ITT1416
- Catalog: ITT1416
- Gene/Protein: RCAN1
- Product Description: Immunotag™ DSCR 1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | DSCR 1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from DSCR 1, at AA range: 180-260 |
| Specificity | DSCR 1 Polyclonal Antibody detects endogenous levels of DSCR 1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RCAN1 |
| Accession No. | P53805 Q9JHG6 Q6IN33 |
| Alternate Names | RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1 |
| Description | regulator of calcineurin 1(RCAN1) Homo sapiens The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013], |
| Cell Pathway/ Category | B_Cell_Antigen |
| Protein Expression | Heart,Lung,Mammary gland,Tongue,Uterus, |
| Subcellular Localization | intracellular,nucleus,cytoplasm, |
| Protein Function | function:Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.,induction:By calcium.,similarity:Belongs to the RCAN family.,tissue specificity:Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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