ITT1678
ITT1678
- Catalog: ITT1678
- Gene/Protein: FASTK
- Product Description: Immunotag™ FAST Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FAST |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410 |
| Specificity | FAST Polyclonal Antibody detects endogenous levels of FAST protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FASTK |
| Accession No. | Q14296 Q9JIX9 |
| Alternate Names | FASTK; Fas-activated serine/threonine kinase; FAST kinase |
| Description | Fas activated serine/threonine kinase(FASTK) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Kidney,Lung,Lymph node,Peripheral blood lymphocyte,Skin, |
| Subcellular Localization | mitochondrial matrix, |
| Protein Function | catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].,function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.,PTM:Phosphorylated on serine/threonine.,similarity:Belongs to the FAST protein kinase family.,similarity:Contains 1 RAP domain.,subunit:Interacts with TIA-1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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