ITT1936
ITT1936
ITT1936
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- Catalog: ITT1936
- Gene/Protein: B4GALNT1
- Product Description: Immunotag™ GM2/GD2 synthase Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein GM2/GD2 synthase Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from GM2/GD2 synthase, at AA range: 250-330 Specificity GM2/GD2 synthase Polyclonal Antibody detects endogenous levels of GM2/GD2 synthase protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name B4GALNT1 Accession No. Q00973 Q09200 Q10468 Alternate Names B4GALNT1; GALGT; SIAT2; Beta-1; 4 N-acetylgalactosaminyltransferase 1; (N-acetylneuraminyl)-galactosylglucosylceramide; GM2/GD2 synthase; GalNAc-T Description beta-1,4-N-acetyl-galactosaminyltransferase 1(B4GALNT1) Homo sapiens GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013], Cell Pathway/ Category Glycosphingolipid biosynthesis, Protein Expression Brain, Subcellular Localization plasma membrane,membrane,integral component of Golgi membrane, Protein Function catalytic activity:UDP-N-acetyl-D-galactosamine + 1-O-(O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide = UDP + 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminosyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide.,function:Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,subunit:Homodimer; disulfide-linked., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | GM2/GD2 synthase |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from GM2/GD2 synthase, at AA range: 250-330 |
| Specificity | GM2/GD2 synthase Polyclonal Antibody detects endogenous levels of GM2/GD2 synthase protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | B4GALNT1 |
| Accession No. | Q00973 Q09200 Q10468 |
| Alternate Names | B4GALNT1; GALGT; SIAT2; Beta-1; 4 N-acetylgalactosaminyltransferase 1; (N-acetylneuraminyl)-galactosylglucosylceramide; GM2/GD2 synthase; GalNAc-T |
| Description | beta-1,4-N-acetyl-galactosaminyltransferase 1(B4GALNT1) Homo sapiens GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013], |
| Cell Pathway/ Category | Glycosphingolipid biosynthesis, |
| Protein Expression | Brain, |
| Subcellular Localization | plasma membrane,membrane,integral component of Golgi membrane, |
| Protein Function | catalytic activity:UDP-N-acetyl-D-galactosamine + 1-O-(O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide = UDP + 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminosyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide.,function:Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,subunit:Homodimer; disulfide-linked., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |