ITT1974
ITT1974
ITT1974
from
$424.00
Price in reward points: 424
- Catalog: ITT1974
- Gene/Protein: GPR143
- Product Description: Immunotag™ GPR143 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein GPR143 Clonality Polyclonal Storage/Stability -20°C/1 year Application IF,ELISA Recommended Dilution Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human GPR143. AA range:151-200 Specificity GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name GPR143 Accession No. P51810 P70259 Alternate Names GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein Description G protein-coupled receptor 143(GPR143) Homo sapiens This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009], Protein Expression Melanocyte,Retina,Skin, Subcellular Localization cytoplasm,lysosomal membrane,Golgi apparatus,plasma membrane,membrane,integral component of membrane,apical plasma membrane,melanosome membrane,melanosome, Protein Function disease:Defects in GPR143 are the cause of ocular albinism type 1 (OA1) [MIM:300500]; also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.,function:Not known; binds heterotrimeric G proteins.,online information:GPR143 mutations,online information:Retina International's Scientific Newsletter,similarity:Belongs to the G-protein coupled receptor OA family.,subcellular location:Targeted to intracellular organelles, namely the melanosomes in pigment cells.,tissue specificity:Exclusively expressed in pigment cells., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | GPR143 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,ELISA |
| Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPR143. AA range:151-200 |
| Specificity | GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GPR143 |
| Accession No. | P51810 P70259 |
| Alternate Names | GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein |
| Description | G protein-coupled receptor 143(GPR143) Homo sapiens This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009], |
| Protein Expression | Melanocyte,Retina,Skin, |
| Subcellular Localization | cytoplasm,lysosomal membrane,Golgi apparatus,plasma membrane,membrane,integral component of membrane,apical plasma membrane,melanosome membrane,melanosome, |
| Protein Function | disease:Defects in GPR143 are the cause of ocular albinism type 1 (OA1) [MIM:300500]; also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.,function:Not known; binds heterotrimeric G proteins.,online information:GPR143 mutations,online information:Retina International's Scientific Newsletter,similarity:Belongs to the G-protein coupled receptor OA family.,subcellular location:Targeted to intracellular organelles, namely the melanosomes in pigment cells.,tissue specificity:Exclusively expressed in pigment cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |