ITT2016
ITT2016
ITT2016
from
$424.00
Price in reward points: 424
- Catalog: ITT2016
- Gene/Protein: GPR37
- Product Description: Immunotag™ GPR37 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein GPR37 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from GPR37, at AA range: 180-260 Specificity GPR37 Polyclonal Antibody detects endogenous levels of GPR37 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name GPR37 Accession No. O15354 Q9QY42 Q9QYC6 Alternate Names GPR37; Probable G-protein coupled receptor 37; Endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; PAELR Description G protein-coupled receptor 37(GPR37) Homo sapiens This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012], Cell Pathway/ Category Parkinson's disease, Protein Expression Brain, Subcellular Localization ubiquitin ligase complex,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,integral component of plasma membrane,receptor complex, Protein Function function:Orphan receptor. May have a unique functional role in the central nervous system.,PTM:Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.,tissue specificity:Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ)., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | GPR37 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from GPR37, at AA range: 180-260 |
| Specificity | GPR37 Polyclonal Antibody detects endogenous levels of GPR37 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GPR37 |
| Accession No. | O15354 Q9QY42 Q9QYC6 |
| Alternate Names | GPR37; Probable G-protein coupled receptor 37; Endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; PAELR |
| Description | G protein-coupled receptor 37(GPR37) Homo sapiens This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012], |
| Cell Pathway/ Category | Parkinson's disease, |
| Protein Expression | Brain, |
| Subcellular Localization | ubiquitin ligase complex,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,integral component of plasma membrane,receptor complex, |
| Protein Function | function:Orphan receptor. May have a unique functional role in the central nervous system.,PTM:Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.,tissue specificity:Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |