ITT2111
ITT2111
ITT2111
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- Catalog: ITT2111
- Gene/Protein: HCN2
- Product Description: Immunotag™ HCN2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein HCN2 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC-p,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from HCN2, at AA range: 460-540 Specificity HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name HCN2 Accession No. Q9UL51 O88703 Q9JKA9 Alternate Names HCN2; BCNG2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Brain cyclic nucleotide-gated channel 2; BCNG-2 Description hyperpolarization activated cyclic nucleotide gated potassium channel 2(HCN2) Homo sapiens Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010], Protein Expression Brain,Heart, Subcellular Localization plasma membrane,integral component of plasma membrane,voltage-gated potassium channel complex,HCN channel complex, Protein Function domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.,miscellaneous:Inhibited by extracellular cesium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.,tissue specificity:Highly expressed throughout the brain. Detected at low levels in heart., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | HCN2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from HCN2, at AA range: 460-540 |
| Specificity | HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HCN2 |
| Accession No. | Q9UL51 O88703 Q9JKA9 |
| Alternate Names | HCN2; BCNG2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Brain cyclic nucleotide-gated channel 2; BCNG-2 |
| Description | hyperpolarization activated cyclic nucleotide gated potassium channel 2(HCN2) Homo sapiens Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010], |
| Protein Expression | Brain,Heart, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,voltage-gated potassium channel complex,HCN channel complex, |
| Protein Function | domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.,miscellaneous:Inhibited by extracellular cesium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.,tissue specificity:Highly expressed throughout the brain. Detected at low levels in heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |