ITT2424
ITT2424
- Catalog: ITT2424
- Gene/Protein: JAK1
- Product Description: Immunotag™ JAK1 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | JAK1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IF,WB,IHC-p,ELISA |
Recommended Dilution | IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human JAK1. AA range:988-1037 |
Specificity | JAK1 Polyclonal Antibody detects endogenous levels of JAK1 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | JAK1 |
Accession No. | P23458 P52332 |
Alternate Names | JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1 |
Description | Janus kinase 1(JAK1) Homo sapiens This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
Cell Pathway/ Category | Jak_STAT,Pathways in cancer,Pancreatic cancer, |
Protein Expression | Brain,Colon tumor,Kidney,Lung,Uterus, |
Subcellular Localization | nucleus,cytoplasm,cytosol,cytoskeleton,focal adhesion,endomembrane system,membrane,extrinsic component of cytoplasmic side of plasma membrane, |
Protein Function | catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |