ITT2462
ITT2462
- Catalog: ITT2462
- Gene/Protein: KDELR2
- Product Description: Immunotag™ KDEL Receptor 2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | KDEL Receptor 2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from KDEL Receptor 2, at AA range: 50-130 |
| Specificity | KDEL Receptor 2 Polyclonal Antibody detects endogenous levels of KDEL Receptor 2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KDELR2 |
| Accession No. | P33947 Q9CQM2 Q5U305 |
| Alternate Names | KDELR2; ERD2.2; ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2 |
| Description | KDEL endoplasmic reticulum protein retention receptor 2(KDELR2) Homo sapiens Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing r |
| Cell Pathway/ Category | Vibrio cholerae infection, |
| Protein Expression | Brain,Placenta,Skin,Testis,Uterus, |
| Subcellular Localization | Golgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,cis-Golgi network,integral component of membrane,transport vesicle,extracellular exosome, |
| Protein Function | function:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.,similarity:Belongs to the ERD2 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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