ITT2542
ITT2542
ITT2542
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- Catalog: ITT2542
- Gene/Protein: LPHN2
- Product Description: Immunotag™ Latrophilin-2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein LatrophIL-in-2 Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,IF,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from Latrophilin-2, at AA range: 520-600 Specificity Latrophilin-2 Polyclonal Antibody detects endogenous levels of Latrophilin-2 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name LPHN2 Accession No. O95490 Q8JZZ7 O88923 Alternate Names LPHN2; KIAA0786; LEC1; LPHH1; Latrophilin-2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Latrophilin homolog 1; Lectomedin-1 Description adhesion G protein-coupled receptor L2(ADGRL2) Homo sapiens This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], Protein Expression Brain,Liver, Subcellular Localization integral component of membrane, Protein Function function:Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).,tissue specificity:Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | LatrophIL-in-2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Latrophilin-2, at AA range: 520-600 |
| Specificity | Latrophilin-2 Polyclonal Antibody detects endogenous levels of Latrophilin-2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LPHN2 |
| Accession No. | O95490 Q8JZZ7 O88923 |
| Alternate Names | LPHN2; KIAA0786; LEC1; LPHH1; Latrophilin-2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Latrophilin homolog 1; Lectomedin-1 |
| Description | adhesion G protein-coupled receptor L2(ADGRL2) Homo sapiens This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], |
| Protein Expression | Brain,Liver, |
| Subcellular Localization | integral component of membrane, |
| Protein Function | function:Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).,tissue specificity:Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |