ITT2751
ITT2751
ITT2751
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- Catalog: ITT2751
- Gene/Protein: MGST1
- Product Description: Immunotag™ MGST1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein MGST1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human MGST1. AA range:42-91 Specificity MGST1 Polyclonal Antibody detects endogenous levels of MGST1 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name MGST1 Accession No. P10620 Q91VS7 Alternate Names MGST1; GST12; MGST; Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I Description microsomal glutathione S-transferase 1(MGST1) Homo sapiens The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012], Cell Pathway/ Category Glutathione metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism, Protein Expression Foreskin,Liver,Prostate, Subcellular Localization nucleus,mitochondrion,mitochondrial outer membrane,mitochondrial inner membrane,peroxisomal membrane,endoplasmic reticulum,endoplasmic reticulum membrane,integral component of membrane,apical part of cell, Protein Function catalytic activity:RX + glutathione = HX + R-S-glutathione.,enzyme regulation:Activated by N-ethylmaleimide, except in the testis.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,tissue specificity:Highly expressed in liver., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | MGST1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MGST1. AA range:42-91 |
| Specificity | MGST1 Polyclonal Antibody detects endogenous levels of MGST1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MGST1 |
| Accession No. | P10620 Q91VS7 |
| Alternate Names | MGST1; GST12; MGST; Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I |
| Description | microsomal glutathione S-transferase 1(MGST1) Homo sapiens The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012], |
| Cell Pathway/ Category | Glutathione metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism, |
| Protein Expression | Foreskin,Liver,Prostate, |
| Subcellular Localization | nucleus,mitochondrion,mitochondrial outer membrane,mitochondrial inner membrane,peroxisomal membrane,endoplasmic reticulum,endoplasmic reticulum membrane,integral component of membrane,apical part of cell, |
| Protein Function | catalytic activity:RX + glutathione = HX + R-S-glutathione.,enzyme regulation:Activated by N-ethylmaleimide, except in the testis.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,tissue specificity:Highly expressed in liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |