ITT3042
ITT3042
- Catalog: ITT3042
- Gene/Protein: NTN1
- Product Description: Immunotag™ Netrin-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Netrin-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Netrin-1 |
| Specificity | Netrin-1 Polyclonal Antibody detects endogenous levels of Netrin-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NTN1 |
| Accession No. | O95631 O09118 Q924Z9 |
| Alternate Names | NTN1; NTN1L; Netrin-1; Epididymis tissue protein Li 131P |
| Description | netrin 1(NTN1) Homo sapiens Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Axon guidance, |
| Protein Expression | Brain stem,Liver, |
| Subcellular Localization | extracellular region,basement membrane,cytoplasm, |
| Protein Function | disease:Defects in NTN1 are associated with some forms of neuroblastomas.,function:Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 1 NTR domain.,similarity:Contains 3 laminin EGF-like domains.,subunit:Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D.,tissue specificity:Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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