ITT3149
ITT3149
ITT3149
from
$424.00
Price in reward points: 424
- Catalog: ITT3149
- Gene/Protein: GRIN2A/GRIN2B
- Product Description: Immunotag™ NMDAε1/2 Polyclonal Antibody
-
Description
-
Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein NMDAε1/2 Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,IF,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from NMDAε1/2, at AA range: 1190-1270 Specificity NMDAε1/2 Polyclonal Antibody detects endogenous levels of NMDAε1/2 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name GRIN2A/GRIN2B Accession No. Q12879/Q13224 Q00959/Q00960 Alternate Names GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N Description glutamate ionotropic receptor NMDA type subunit 2A(GRIN2A) Homo sapiens This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], Cell Pathway/ Category Calcium,Neuroactive ligand-receptor interaction,Long-term potentiation,Alzheimer's disease,Amyotrophic lateral sclerosis (ALS),Systemic lupus erythematosus, Protein Expression Brain,Cerebellum,Epithelium,Hippocampus, Subcellular Localization endoplasmic reticulum,plasma membrane,integral component of plasma membrane,synaptic vesicle,cell surface,postsynaptic density,integral component of membrane,NMDA selective glutamate receptor complex,cell junction,pres Protein Function function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4. Interacts with HIP1., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | NMDAε1/2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from NMDAε1/2, at AA range: 1190-1270 |
| Specificity | NMDAε1/2 Polyclonal Antibody detects endogenous levels of NMDAε1/2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GRIN2A/GRIN2B |
| Accession No. | Q12879/Q13224 Q00959/Q00960 |
| Alternate Names | GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N |
| Description | glutamate ionotropic receptor NMDA type subunit 2A(GRIN2A) Homo sapiens This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction,Long-term potentiation,Alzheimer's disease,Amyotrophic lateral sclerosis (ALS),Systemic lupus erythematosus, |
| Protein Expression | Brain,Cerebellum,Epithelium,Hippocampus, |
| Subcellular Localization | endoplasmic reticulum,plasma membrane,integral component of plasma membrane,synaptic vesicle,cell surface,postsynaptic density,integral component of membrane,NMDA selective glutamate receptor complex,cell junction,pres |
| Protein Function | function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4. Interacts with HIP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |