ITT3214
ITT3214
ITT3214
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- Catalog: ITT3214
- Gene/Protein: NXF3
- Product Description: Immunotag™ NXF3 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein NXF3 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC-p,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human NXF3. AA range:72-121 Specificity NXF3 Polyclonal Antibody detects endogenous levels of NXF3 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name NXF3 Accession No. Q9H4D5 Alternate Names NXF3; TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3 Description nuclear RNA export factor 3(NXF3) Homo sapiens This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008], Protein Expression Brain,Fetal brain,Testis, Subcellular Localization nucleus,nucleoplasm,cytoplasm,nuclear RNA export factor complex, Protein Function domain:Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.,domain:Lacks C-terminal domain that mediates direct interactions with nucleoporins.,function:May function as a tissue-specific nuclear mRNA export factor.,miscellaneous:The RNA-binding domain is a non-canonical RNP-type domain.,similarity:Belongs to the NXF family.,similarity:Contains 1 LRR (leucine-rich) repeat.,similarity:Contains 1 NTF2 domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.,tissue specificity:Expressed at high level in testis and at low level in a small number of tissues., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | NXF3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NXF3. AA range:72-121 |
| Specificity | NXF3 Polyclonal Antibody detects endogenous levels of NXF3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NXF3 |
| Accession No. | Q9H4D5 |
| Alternate Names | NXF3; TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3 |
| Description | nuclear RNA export factor 3(NXF3) Homo sapiens This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Fetal brain,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,nuclear RNA export factor complex, |
| Protein Function | domain:Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.,domain:Lacks C-terminal domain that mediates direct interactions with nucleoporins.,function:May function as a tissue-specific nuclear mRNA export factor.,miscellaneous:The RNA-binding domain is a non-canonical RNP-type domain.,similarity:Belongs to the NXF family.,similarity:Contains 1 LRR (leucine-rich) repeat.,similarity:Contains 1 NTF2 domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.,tissue specificity:Expressed at high level in testis and at low level in a small number of tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |