ITT3505
ITT3505
ITT3505
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$424.00
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- Catalog: ITT3505
- Gene/Protein: P2RY11
- Product Description: Immunotag™ P2Y11 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein P2Y11 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human P2RY11. AA range:140-189 Specificity P2Y11 Polyclonal Antibody detects endogenous levels of P2Y11 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name P2RY11 Accession No. Q96G91 Alternate Names P2RY11; P2Y purinoceptor 11; P2Y11 Description purinergic receptor P2Y11(P2RY11) Homo sapiens The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Neuroactive ligand-receptor interaction, Protein Expression Brain,Placenta,Promyelocyte, Subcellular Localization intracellular,plasma membrane,integral component of plasma membrane, Protein Function function:Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.,induction:Increased by DMSO and retinoic acid.,miscellaneous:A putative trans-splicing which involves PPAN and P2RY11 gene regions produces a fusion protein.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highest expression in the spleen, lower in the small intestine., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | P2Y11 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human P2RY11. AA range:140-189 |
| Specificity | P2Y11 Polyclonal Antibody detects endogenous levels of P2Y11 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | P2RY11 |
| Accession No. | Q96G91 |
| Alternate Names | P2RY11; P2Y purinoceptor 11; P2Y11 |
| Description | purinergic receptor P2Y11(P2RY11) Homo sapiens The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain,Placenta,Promyelocyte, |
| Subcellular Localization | intracellular,plasma membrane,integral component of plasma membrane, |
| Protein Function | function:Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.,induction:Increased by DMSO and retinoic acid.,miscellaneous:A putative trans-splicing which involves PPAN and P2RY11 gene regions produces a fusion protein.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highest expression in the spleen, lower in the small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |