ITT3851
ITT3851
ITT3851
from
$424.00
Price in reward points: 424
- Catalog: ITT3851
- Gene/Protein: PPRC1
- Product Description: Immunotag™ PRC Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PRC Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human PPRC1. AA range:1609-1658 Specificity PRC Polyclonal Antibody detects endogenous levels of PRC protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name PPRC1 Accession No. Q5VV67 Q6NZN1 Alternate Names PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC Description peroxisome proliferator-activated receptor gamma, coactivator-related 1(PPRC1) Homo sapiens The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013], Protein Expression Brain,Placenta,Uterus, Subcellular Localization nucleus,nucleoplasm, Protein Function function:Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.,induction:Up-regulated by serum (at protein level).,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Colocalizes with NRF1.,subunit:Interacts with CREB1 and NRF1.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PRC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPRC1. AA range:1609-1658 |
| Specificity | PRC Polyclonal Antibody detects endogenous levels of PRC protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PPRC1 |
| Accession No. | Q5VV67 Q6NZN1 |
| Alternate Names | PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC |
| Description | peroxisome proliferator-activated receptor gamma, coactivator-related 1(PPRC1) Homo sapiens The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013], |
| Protein Expression | Brain,Placenta,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm, |
| Protein Function | function:Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.,induction:Up-regulated by serum (at protein level).,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Colocalizes with NRF1.,subunit:Interacts with CREB1 and NRF1.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |