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ITT3895

ITT3895
  • Catalog: ITT3895
  • Gene/Protein: PPP1R3C
  • Product Description: Immunotag™ PTG Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ PTG Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PTG
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Monkey
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human PPP1R3C. AA range:44-93
Specificity PTG Polyclonal Antibody detects endogenous levels of PTG protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PPP1R3C
Accession No. Q9UQK1 Q7TMB3
Alternate Names PPP1R3C; PPP1R5; Protein phosphatase 1 regulatory subunit 3C; Protein phosphatase 1 regulatory subunit 5; PP1 subunit R5; Protein targeting to glycogen; PTG
Description protein phosphatase 1 regulatory subunit 3C(PPP1R3C) Homo sapiens This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016],
Cell Pathway/ Category Insulin_Receptor,
Protein Expression Gall bladder,Retina,Skeletal muscle,
Subcellular Localization cytosol,
Protein Function domain:The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.,function:Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.,similarity:Contains 1 CBM21 (carbohydrate binding type-21) domain.,subunit:Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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