ITT3942
ITT3942
ITT3942
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- Catalog: ITT3942
- Gene/Protein: RAB11FIP1
- Product Description: Immunotag™ Rab11-FIP1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein Rab11-FIP1 Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from Rab11-FIP1 . at AA range: 70-150 Specificity Rab11-FIP1 Polyclonal Antibody detects endogenous levels of Rab11-FIP1 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name RAB11FIP1 Accession No. Q6WKZ4 Q9D620 Alternate Names RAB11FIP1; RCP; Rab11 family-interacting protein 1; Rab11-FIP1; Rab-coupling protein Description RAB11 family interacting protein 1(RAB11FIP1) Homo sapiens This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013], Cell Pathway/ Category Endocytosis, Protein Expression Cervix carcinoma,Epithelium,Gastric,Gastric antrum,Lung,Placenta,Sm Subcellular Localization cytoplasm,phagocytic vesicle membrane,intracellular membrane-bounded organelle,recycling endosome, Protein Function function:A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.,similarity:Contains 1 C2 domain.,subcellular location:Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).,subcellular location:Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).,subunit:Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.,tissue specificity:Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | Rab11-FIP1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Rab11-FIP1 . at AA range: 70-150 |
| Specificity | Rab11-FIP1 Polyclonal Antibody detects endogenous levels of Rab11-FIP1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RAB11FIP1 |
| Accession No. | Q6WKZ4 Q9D620 |
| Alternate Names | RAB11FIP1; RCP; Rab11 family-interacting protein 1; Rab11-FIP1; Rab-coupling protein |
| Description | RAB11 family interacting protein 1(RAB11FIP1) Homo sapiens This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013], |
| Cell Pathway/ Category | Endocytosis, |
| Protein Expression | Cervix carcinoma,Epithelium,Gastric,Gastric antrum,Lung,Placenta,Sm |
| Subcellular Localization | cytoplasm,phagocytic vesicle membrane,intracellular membrane-bounded organelle,recycling endosome, |
| Protein Function | function:A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.,similarity:Contains 1 C2 domain.,subcellular location:Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).,subcellular location:Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).,subunit:Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.,tissue specificity:Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |