ITT3991
ITT3991
ITT3991
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$424.00
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- Catalog: ITT3991
- Gene/Protein: RRAGB
- Product Description: Immunotag™ Rag B Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein Rag B Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from Rag B, at AA range: 50-130 Specificity Rag B Polyclonal Antibody detects endogenous levels of Rag B protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name RRAGB Accession No. Q5VZM2 Q6NTA4 Q63487 Alternate Names RRAGB; Ras-related GTP-binding protein B; Rag B; RagB Description Ras related GTP binding B(RRAGB) Homo sapiens Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008], Cell Pathway/ Category mTOR Protein Expression Adipose tissue,Brain,Skin, Subcellular Localization nucleus,cytoplasm,lysosome,lysosomal membrane,Golgi apparatus,cytosol,EGO complex,intracellular membrane-bounded organelle,Gtr1-Gtr2 GTPase complex, Protein Function function:Involved in the RCC1/Ran-GTPase pathway. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subunit:The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | Rag B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Rag B, at AA range: 50-130 |
| Specificity | Rag B Polyclonal Antibody detects endogenous levels of Rag B protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RRAGB |
| Accession No. | Q5VZM2 Q6NTA4 Q63487 |
| Alternate Names | RRAGB; Ras-related GTP-binding protein B; Rag B; RagB |
| Description | Ras related GTP binding B(RRAGB) Homo sapiens Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | mTOR |
| Protein Expression | Adipose tissue,Brain,Skin, |
| Subcellular Localization | nucleus,cytoplasm,lysosome,lysosomal membrane,Golgi apparatus,cytosol,EGO complex,intracellular membrane-bounded organelle,Gtr1-Gtr2 GTPase complex, |
| Protein Function | function:Involved in the RCC1/Ran-GTPase pathway. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subunit:The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |