ITT3995
ITT3995
- Catalog: ITT3995
- Gene/Protein: GPRC5A
- Product Description: Immunotag™ RAI3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | RAI3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPRC5A. AA range:140-189 |
| Specificity | RAI3 Polyclonal Antibody detects endogenous levels of RAI3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GPRC5A |
| Accession No. | Q8NFJ5 Q8BHL4 |
| Alternate Names | GPRC5A; GPCR5A; RAI3; RAIG1; Retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; Orphan G-protein-coupling receptor PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1 |
| Description | G protein-coupled receptor class C group 5 member A(GPRC5A) Homo sapiens This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008], |
| Protein Expression | Colon,Colon carcinoma,Epithelium,Lung, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,cell-cell adherens junction,integral component of membrane,cytoplasmic vesicle membrane,vesicle,intracellular membrane-bounded organelle,extracellular exosome, |
| Protein Function | function:Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.,induction:By all-trans retinoic acid (ATRA).,similarity:Belongs to the G-protein coupled receptor 3 family.,subcellular location:Localized in the plasma membrane and perinuclear vesicles.,tissue specificity:Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259: expressed at low but detectable level in pancreas and heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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