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ITT4578

ITT4578
  • Catalog: ITT4578
  • Gene/Protein: TCF7L1
  • Product Description: Immunotag™ TCF-3 Polyclonal Antibody
334.0000
Price in reward points: 334

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Immunotag™ TCF-3 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein TCF-3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human TCF7L1. AA range:321-370
Specificity TCF-3 Polyclonal Antibody detects endogenous levels of TCF-3 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name TCF7L1
Accession No. Q9HCS4 Q9Z1J1
Alternate Names TCF7L1; TCF3; Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3
Description transcription factor 7 like 1(TCF7L1) Homo sapiens This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010],
Cell Pathway/ Category Stem cell pathway, Adherens_Junction, Protein_Acetylation
Protein Expression Eye,Fetal lung,
Subcellular Localization nucleus,nucleoplasm,transcription factor complex,
Protein Function domain:The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.,function:Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.,similarity:Belongs to the TCF/LEF family.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex.,tissue specificity:Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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