ITT4920
ITT4920
ITT4920
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$424.00
Price in reward points: 424
- Catalog: ITT4920
- Gene/Protein: XRCC3
- Product Description: Immunotag™ XRCC3 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein XRCC3 Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,IF,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human XRCC3. AA range:41-90 Specificity XRCC3 Polyclonal Antibody detects endogenous levels of XRCC3 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name XRCC3 Accession No. O43542 Q9CXE6 Alternate Names XRCC3; DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 Description X-ray repair cross complementing 3(XRCC3) Homo sapiens This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Homologous recombination, Protein Expression Cerebellum,Cervix carcinoma,Lymph,Muscle,Neuroblastoma,Placenta, Subcellular Localization nuclear chromosome, telomeric region,nucleus,nucleoplasm,replication fork,cytoplasm,mitochondrion,Rad51B-Rad51C-Rad51D-XRCC2 complex,Rad51C-XRCC3 complex,perinuclear region of cytoplasm, Protein Function disease:Met-241 is associated with the development of cutaneous malignant melanoma.,function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | XRCC3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human XRCC3. AA range:41-90 |
| Specificity | XRCC3 Polyclonal Antibody detects endogenous levels of XRCC3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | XRCC3 |
| Accession No. | O43542 Q9CXE6 |
| Alternate Names | XRCC3; DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 |
| Description | X-ray repair cross complementing 3(XRCC3) Homo sapiens This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Homologous recombination, |
| Protein Expression | Cerebellum,Cervix carcinoma,Lymph,Muscle,Neuroblastoma,Placenta, |
| Subcellular Localization | nuclear chromosome, telomeric region,nucleus,nucleoplasm,replication fork,cytoplasm,mitochondrion,Rad51B-Rad51C-Rad51D-XRCC2 complex,Rad51C-XRCC3 complex,perinuclear region of cytoplasm, |
| Protein Function | disease:Met-241 is associated with the development of cutaneous malignant melanoma.,function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |