ITT5234
ITT5234
ITT5234
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$424.00
Price in reward points: 424
- Catalog: ITT5234
- Gene/Protein: LASP1
- Product Description: Immunotag™ LASP-1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein LASP-1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from LASP-1, at AA range: internal Specificity LASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name LASP1 Accession No. Q14847 Q61792 Q99MZ8 Alternate Names LASP1; MLN50; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50 Description LIM and SH3 protein 1(LASP1) Homo sapiens This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012], Protein Expression Epithelium,Liver,Mammary carcinoma,Platelet,Skin,T-cell, Subcellular Localization cytoplasm,cell-cell adherens junction,focal adhesion,cortical actin cytoskeleton,extracellular exosome, Protein Function function:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | LASP-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from LASP-1, at AA range: internal |
| Specificity | LASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LASP1 |
| Accession No. | Q14847 Q61792 Q99MZ8 |
| Alternate Names | LASP1; MLN50; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50 |
| Description | LIM and SH3 protein 1(LASP1) Homo sapiens This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012], |
| Protein Expression | Epithelium,Liver,Mammary carcinoma,Platelet,Skin,T-cell, |
| Subcellular Localization | cytoplasm,cell-cell adherens junction,focal adhesion,cortical actin cytoskeleton,extracellular exosome, |
| Protein Function | function:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |