ITT5492
ITT5492
ITT5492
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$424.00
Price in reward points: 424
- Catalog: ITT5492
- Gene/Protein: HLA-DQB1/HLA-DQB2
- Product Description: Immunotag™ HLA-DQB1/2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein HLA-DQB1/2 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC-p,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQB1/HLA-DQB2. AA range:131-180 Specificity HLA-DQB1/2 Polyclonal Antibody detects endogenous levels of HLA-DQB1/2 protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name HLA-DQB1/HLA-DQB2 Accession No. P01920/P05538 Alternate Names HLA-DQB1; HLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; MHC class II antigen DQB1; HLA-DQB2; HLA-DXB; HLA class II histocompatibility antigen, DQ beta 2 chainHLA class II histocompatibility antigen, DX beta chain; MHC class II antigen DQB2 Description major histocompatibility complex, class II, DQ beta 1(HLA-DQB1) Homo sapiens HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro Cell Pathway/ Category Cell adhesion molecules (CAMs),Antigen processing and presentation,Intestinal immune network for IgA production,Type I diabetes mellitus,Asthma,Autoimmune thyroid disease,Systemic lupus erythematosus,Allograft rejection,Graft-versus-host disease,Viral myocarditis, Protein Expression B-cell,Blood,Colon,Peripheral blood,Peripheral bloo Subcellular Localization Golgi membrane,lysosomal membrane,plasma membrane,endosome membrane,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,transport vesicle membrane,endocytic vesicle membrane,clathrin-coated e Protein Function caution:PubMed:6954511 have called the protein an HLA-DR antigen-like beta-chain.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | HLA-DQB1/2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQB1/HLA-DQB2. AA range:131-180 |
| Specificity | HLA-DQB1/2 Polyclonal Antibody detects endogenous levels of HLA-DQB1/2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HLA-DQB1/HLA-DQB2 |
| Accession No. | P01920/P05538 |
| Alternate Names | HLA-DQB1; HLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; MHC class II antigen DQB1; HLA-DQB2; HLA-DXB; HLA class II histocompatibility antigen, DQ beta 2 chainHLA class II histocompatibility antigen, DX beta chain; MHC class II antigen DQB2 |
| Description | major histocompatibility complex, class II, DQ beta 1(HLA-DQB1) Homo sapiens HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Antigen processing and presentation,Intestinal immune network for IgA production,Type I diabetes mellitus,Asthma,Autoimmune thyroid disease,Systemic lupus erythematosus,Allograft rejection,Graft-versus-host disease,Viral myocarditis, |
| Protein Expression | B-cell,Blood,Colon,Peripheral blood,Peripheral bloo |
| Subcellular Localization | Golgi membrane,lysosomal membrane,plasma membrane,endosome membrane,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,transport vesicle membrane,endocytic vesicle membrane,clathrin-coated e |
| Protein Function | caution:PubMed:6954511 have called the protein an HLA-DR antigen-like beta-chain.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |