Datasheet |
|
Target Protein |
PI 3 Kinase Class 3 |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
WB,ELISA |
Recommended Dilution |
WB 1:500-2000, ELISA 1:10000-20000 |
Concentration |
1 mg/ml |
Reactive Species |
Human,Mouse,Rat,Predicted:Cow:PIG |
Host Species |
Rabbit |
Immunogen |
Synthetic Peptide of PI 3 Kinase Class 3 |
Specificity |
PI 3 Kinase Class 3 Polyclonal Antibody detects endogenous levels of PI 3 Kinase Class 3 |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name |
PIK3C3 VPS34 |
Accession No. |
Q8NEB9 Q6PF93 O88763 |
Alternate Names |
phosphoinositide-3-kinase, class 3 |
Description |
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle., |
Cell Pathway/ Category |
Inositol phosphate metabolism,Phosphatidylinositol signaling system,Regulation of autophagy, |
Protein Expression |
Testis,Uterus, |
Subcellular Localization |
intracellular,late endosome,cytosol,axoneme,phosphatidylinositol 3-kinase complex,membrane,midbody,phagocytic vesicle membrane,phosphatidylinositol 3-kinase complex, class III,autolysosome, |
Protein Function |
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |